Wine Information Council
14 march 2025
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Effect of moderate wine consumption on the activity of enzymes involved in platelet-activating factor metabolism and thrombotic biomarkers: a randomised, single-blind, parallel, clinical study in CHD men patients

A randomised parallel intervention study was conducted with male patients diagnosed with CHD. Participants were assigned to three groups: Group A abstained from alcohol (n 20), Group B consumed red wine (n 21) and Group C (n 16) consumed an alcoholic beverage without wine micro-constituents. Biological samples were collected at baseline, 4 and 8 weeks. Enzyme activities of acetyl-CoA:lyso-platelet-activating factor (PAF) acetyltransferase, cytidine 5′-diphospho (CDP)-choline:1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase (PAF-cholinephosphotransferase), PAF-acetylhydrolase in leukocyte homogenates, serum lipoprotein-associated phospholipase-A(2) and plasma markers of thrombosis were measured. PAF-, ADP- and collagen-induced platelet aggregation was measured in human platelet-rich plasma. Red wine consumption led to a 15.3 % reduction in LysoPAF-acetyltransferase activity at 4 weeks (P= 0.008) compared with baseline and Group A (P= 0.01). PAF-cholinephosphotransferase activity was reduced by 11.1 % at 8 weeks (P= 0.04) compared with baseline and by 24.9 % compared with Group C (P= 0.02). PAF-acetylhydrolase activity was reduced by 36.2 % at 8 weeks compared with baseline (P= 0.001) and compared with Group A (P< 0.000) and Group C (P= 0.009). Fibrinogen levels in Group B reduced by 6-9 % at 4 (P= 0.04) and 8 weeks (P= 0.01) compared with baseline while D-dimer in Group C increased by 16.1 % at 8 weeks (P= 0.005) compared with baseline. Platelet aggregation against PAF and collagen was reduced in Group B (82.6 and 35.4 %, respectively), and in Group C (158.4 and 37.1 %, respectively) compared with baseline and Group A (P< 0.05). In conclusion, moderate wine consumption improved the activity of PAF-metabolism enzymes regardless of ethanol and reduced platelet aggregation, probably through mechanisms different from those of ethanol.

Additional Info

  • Authors

    Fragopoulou E.; Argyrou C.; Matalliotaki E.; Pafilas C.; Detopoulou M.; Antonopoulou S.; Kolovou G.; Kalogeropoulos P.

  • Issue

    Periodical: Br J Nutr - Volume: 133 - Number: 5 - Edition: 20250213

  • Published Date

    14 march 2025

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