Wine Information Council
1 september 2025
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A multi-metabolite signature robustly predicts long-term mortality in the PREDIMED trial and several US cohorts

Metabolome-based biomarkers contribute to identify mechanisms of disease and to a better understanding of overall mortality. In a long-term follow-up subsample (n = 1878) of the PREDIMEDThe PREDIMED study is one of the few randomized controlled trials about the Mediterranean Diet. More... trial, among 337 candidate baseline plasma metabolites repeatedly assessed at baseline and after 1 year, 38 plasma metabolites were identified as predictors of all-cause mortality. Gamma-amino-butyric acid (GABA), homoarginine, serine, creatine, 1-methylnicotinamide and a set of sphingomyelins, plasmalogens, phosphatidylethanolamines and cholesterol esters were inversely associated with all-cause mortality, whereas plasma dimethylguanidino valeric acid (DMGV), choline, short and long-chain acylcarnitines, 4-acetamidobutanoate, pseudouridine, 7-methylguanine, N6-acetyllysine, phenylacetylglutamine and creatinine were associated with higher mortality. The multi-metabolite signature created as a linear combination of these selected metabolites, also showed a strong association with all-cause mortality using plasma samples collected at 1-year follow-up in PREDIMEDThe PREDIMED study is one of the few randomized controlled trials about the Mediterranean Diet. More.... This association was subsequently confirmed in 4 independent American cohorts, validating the signature as a consistent predictor of all-cause mortality across diverse populations.

Additional Info

  • Authors

    Fernández-Duval Gonzalo; Razquin Cristina; Wang Fenglei; Yun Huan; Hu Jie; Guasch-Ferré Marta; Rexrode Kathryn; Balasubramanian Raji; García-Gavilán Jesús; Ruiz-Canela Miguel; Clish Clary B.; Corella Dolores; Gómez-Gracia Enrique; Fiol Miquel; Estruch Ramón; Lapetra José; Fitó Montse; Serra-Majem Luis; Ros Emilio; Liang Liming; Dennis Courtney; Asensio Eva M.; Castañer Olga; Planes Francisco J.; Salas-Salvadó Jordi; Hu Frank B.; Toledo Estefanía; Martínez-González Miguel A.

  • Issue

    Periodical: Metabolism - Volume: 170

  • Published Date

    1 september 2025

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