Wine Information Council
30 august 2025
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Relationship between moderate alcohol consumption and all-cause mortality across different stages of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: a cohort study

BACKGROUND AND AIM: The health effects of moderate alcohol consumption remain inconclusive. The Cardiovascular-Kidney-Metabolic Syndrome (CKM) is a novel concept that involves various health conditions. This study aimed to investigate the association between moderate alcohol consumption and all-cause mortality in different stages of CKM within the UK Biobank cohort, and to validate the findings in the NHANES population.

METHODS AND RESULTS: This study included 112,207 participants from the UK Biobank cohort, stratified by different stages of CKM. Multiple covariates were incorporated to explore the relationship between moderate alcohol consumption and all-cause mortality. Additionally, 10,904 participants from the NHANES cohort were analysed, stratified by sex, with restricted cubic spline (RCS) curves plotted for corroboration. In the UK Biobank, moderate alcohol consumption was associated with increased all-cause mortality, whereas no significant association was found in the NHANES cohort. Among the CKM stages, moderate drinking was positively correlated with all-cause mortality in males and females in stage II and males in stage IV, whereas no significant associations were observed in the other stages. The RCS curves revealed a positive correlation between alcohol consumption and all-cause mortality for both genders, with females showing greater sensitivity to alcohol than males.

CONCLUSIONS: While previous studies have suggested potential benefits of moderate alcohol consumption, a positive correlation between alcohol consumption and all-cause mortality was observed for both genders in our study. Therefore, even moderate alcohol intake warrants caution, and efforts should be made to minimize alcohol consumption.

Additional Info

  • Authors

    Wang Z.; Hu L.; Chen A.; Wu Y.; Wang G.; Xie X.; He Q.; Xue Y.; Lin J.; Zheng Z.; Jia Y.; Chen J.

  • Issue

    Periodical: Nutr Metab Cardiovasc Dis - Edition: 20250830

  • Published Date

    30 august 2025

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