Wine Information Council
june 2019
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Host-Microbe Interplay in the Cardiometabolic Benefits of Dietary Polyphenols

PolyphenolsPolyphenols are mainly phytochemicals found abundantly in natural plant food sources. The most impor... are nonessential phytonutrients abundantly found in fruits and vegetables. A wealth of data from preclinical models and clinical trials consistently supports cardiometabolic benefits associated with dietary polyphenols in murine models and humans.

Furthermore, a growing number of studies have shown that specific classes of polyphenols, such as proanthocyanidins (PACs) and ellagitannins, as well as the stilbenoid resveratrol, can alleviate several features of the metabolic syndrome. Moreover, mounting evidence points to the gut microbiota as a key mediator of the health benefits of polyphenols.

In this review we summarize recent findings supporting the beneficial potential of polyphenols against cardiometabolic diseases, with a focus on the role of host-microbe interactions.

Additional Info

  • Authors

    Anhe F. F.; Choi B. S. Y.; Dyck J. R. B.; Schertzer J. D.; Marette A.

  • Issue

    Trends Endocrinol Metab . 2019 Jun;30(6):384-395

  • Published Date

    june 2019

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