Wine Information Council
april 2009
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High dose of red wine elicits enhanced inhibition of fibrinolysis

BACKGROUND AND DESIGN: The purpose of this randomized controlled cross-over study was to determine the acute effects of high doses of alcoholic beverages on circulating markers related to atherosclerosis and fibrinolysis.

METHODS: Twenty-two healthy men consumed a high dose (8.1+/-0.9 dl) of alcohol-containing red wine and dealcoholized red wine, and an equal ethanol dose of cognac (2.4+/-0.3 dl). Blood samples were taken before and shortly after interventions.

RESULTS: Red wine, unlike dealcoholized red wine and cognac, increased tissue plasminogen activator inhibitor-1 levels significantly, indicating an acute inhibition of fibrinolysis after a high dose.

CONCLUSION: Findings may explain the increased risk of cardiovascular mortality among binge drinkers.

Additional Info

  • Authors

    Kiviniemi T.O.; Saraste A.; Lehtimaki T.; Toikka J.O.; Saraste M.; Raitakari O.T.; Parkka J.P.; Hartiala J.J.; Viikari J.; Koskenvuo J.W.

  • Issue

    Eur.J.Cardiovasc.Prev.Rehabil. / pages 161-163 / volume 16

  • Published Date

    april 2009

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