Heavy Alcohol Consumption is Associated with Impaired Endothelial Function
AIM: Previous studies have reported that moderate alcohol consumption is protective against cardiovascular disease, but heavy alcohol consumption increases its risk. Endothelial dysfunctionEndothelial dysfunction is a condition in which the endothelium (inner lining) of blood vessels fail... is hypothesized to contribute to the development of atherosclerosis and cardiovascular disease. However, few population-based studies have examined a potential effect of alcohol consumption on endothelial function.
METHODS: This study included 404 men aged 30-79 years who were recruited from residents in 2 communities under the Circulatory Risk in Communities Study in 2013 and 2014. We asked the individuals about the frequency and volume of alcohol beverages and converted the data into grams of ethanol per day. Endothelial function was assessed by brachial artery flow-mediated dilation (FMD) measurements during reactive hyperemia. We performed cross-sectional analysis of alcohol consumption and %FMD by logistic regression analysis, adjusting for age, baseline brachial artery diameter, body mass index, systolic blood pressure, low-density lipoprotein cholesterol, HbA1c, smoking, antihypertensive medication use, and community.
RESULTS: Individuals who drank >/= 46 g/day ethanol had a lower age-adjusted mean %FMD than non-drinkers (p0.01). Compared with non-drinkers, the age-adjusted odds ratios (ORs) (95% confidence interval) of low %FMD (5.3%) for former, light (23.0 g/day ethanol), moderate (23.0-45.9 g/day ethanol), and heavy (>/= 46.0 g/day ethanol) drinkers were 1.61 (0.67-3.89), 0.84 (0.43-1.66), 1.09 (0.52-2.25), and 2.99 (1.56-5.70), respectively. The corresponding multivariable-adjusted ORs were 1.76 (0.69-4.50), 0.86 (0.42-1.76), 0.98 (0.45-2.12), and 2.39 (1.15-4.95), respectively.
CONCLUSIONS: Heavy alcohol consumption may be an independent risk factor of endothelial dysfunction in Japanese men.
Additional Info
-
Authors
Tanaka A.; Cui R.; Kitamura A.; Liu K.; Imano H.; Yamagishi K.; Kiyama M.; Okada T.; Iso H. -
Issue
J Atheroscler Thromb. 2016 Mar 29. [Epub ahead of print] -
Published Date
29 march 2016
Related items
- Cardiovascular disease risk under low-fat, Mediterranean, and American Heart Association diets: a target trial emulation in United States adults
- Link between alcohol consumption and myocardial infarction, stroke, and all-cause mortality among Swedish male automotive workers over 30 years
- Global Geospatial Trends in Breast Cancer and Atrial Fibrillation/Flutter Among Older Women: Uncovering Shared Epidemiological Patterns and Etiological Links
- The interaction of age and total lifetime drinks is associated with regional cortical perfusion and thickness in healthy adults with low-level alcohol consumption
- Target Trial Emulation of Alcohol Intake Interventions in Young Adults and Risk of CVD over 30 years: Data from the CARDIA study