Decreases in serum alpha-Klotho levels in association with levels of regular alcohol drinking and binge drinking among US adults
AIMS: Alcohol consumption is associated with numerous detrimental health outcomes and aging-related disorders. This study aims to investigate the impact of alcohol drinking levels and drinking behavior on serum levels of Klotho protein, an anti-aging biomarker for health and longevity, in middle-aged and older adults.
METHODS: A nationally representative sample of 4225 adults aged 40-79 years from the 2013-2016 National Health and Nutrition Examination Surveys were analyzed using multiple general linear models. Drinking levels were classified as light (consumed </= 2 drinks for men and </= 1 drink for women in a day), moderate (3-4 for men and 2-3 drinks for women), and heavy drinking (>/= 5 for men and >/= 4 drinks for women), according to national guidelines.
RESULTS: Significantly decreased serum a-Klotho levels were found in all levels of drinking in a dose-dependent manner, with weighted geometric means of 798.80 (P = .0238), 774.75 (P = .0006), 751.83 (P = .0027), and 744.33 pg/ml (P < .0001) in light, moderate, heavy, and former heavy drinkers, respectively, compared to non-drinkers (827.69 pg/ml). After adjusting for covariates, moderate drinking was associated with a 6.53% (P < .0001) decrease, heavy drinking with an 8.97% (P = .0004) decrease, and former heavy drinking with an 7.26% (P < .0001) decrease in a-Klotho levels. Similarly, binge drinking >/= 4 days in the past month was associated with a 9.17% (P = .0341) decrease in serum a-Klotho.
CONCLUSIONS: This study demonstrates a significantly inverse relationship between alcohol consumption and serum a-Klotho levels in middle-aged and older adults. Further studies are warranted to elucidate the role of reducing Klotho levels in alcohol-induced health and aging disorders.
Additional Info
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Authors
Fromm D.; Zhu J.; Kim W. B.; Wei Y. -
Issue
Periodical: Alcohol Alcohol - Volume: 60 - Number: 5 -
Published Date
16 july 2025
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