Case-control study of lifetime alcohol consumption and endometrial cancer risk
PURPOSE: Alcohol consumption is hypothesized to increase the risk of endometrial cancer by increasing circulating estrogen levels. This study sought to investigate the association between lifetime alcohol consumption and endometrial cancer risk.
METHODS: We recruited 514 incident endometrial cancer cases and 962 frequency age-matched controls in this population-based case-control study in Alberta, Canada, from 2002 to 2006. Participants completed in-person interviews querying lifetime alcohol consumption and other relevant health and lifestyle factors. Participants reported the usual number of drinks of beer, wine, and liquor consumed; this information was compiled for each drinking pattern reported over the lifetime to estimate average lifetime exposure to alcohol.
RESULTS: Lifetime average alcohol consumption was relatively low (median intake: 3.9 g/day for cases, 4.9 g/day for controls). Compared with lifetime abstainers, women consuming >2.68 and 8.04 g/day alcohol on average over the lifetime showed 38 and 35 % lower risks of endometrial cancer, respectively (p trend = 0.023). In addition, average lifetime consumption of all types of alcohol was associated with decreased risks. There was no evidence for effect modification by body mass index, physical activity, menopausal status, and hormone replacement therapy use combined and effects did not differ by type of endometrial cancer (type I or II).
CONCLUSION: This study provides epidemiologic evidence for an inverse association between relatively modest lifetime average alcohol consumption (approximately 1/4 to 1/2 drink/day) and endometrial cancer risk. The direction of this relation is consistent with previous studies that examined similar levels of alcohol intake.
Additional Info
-
Authors
Friedenreich C.M.; Speidel T.P.; Neilson H.K.; Langley A.R.; Courneya K.S.; Magliocco A.M.; Cook L.S. -
Issue
Cancer Causes Control / pages 1995-2003 / volume 24 -
Published Date
november 2013
Related items
- Joint association of drinking alcohol and obesity in relation to cancer risk: A systematic review and data synthesis
- Alcohol and colorectal cancer risk, subclassified by mutational signatures of DNA mismatch repair deficiency
- The Combined Effects of Alcohol Consumption and Smoking on Cancer Risk by Exposure Level: A Systematic Review and Meta-Analysis
- Alcohol intake and endogenous sex hormones in women: Meta-analysis of cohort studies and Mendelian randomization
- Joint association of biological aging and lifestyle with risks of cancer incidence and mortality: A cohort study in the UK Biobank