Binge Drinking and Hypertension on Cardiovascular Disease Mortality in Korean Men and Women. A Kangwha Cohort Study
BACKGROUND AND PURPOSE: The purpose of this study was to examine combined effects of hypertension and binge drinking on the risk of mortality from cardiovascular disease in Koreans.
METHODS: This study followed a cohort of 6100 residents in Kangwha County, aged >/=55 years as of March 1985, for cardiovascular mortality for 20.8 years up to December 31, 2005. We calculated hazard ratios (HRs) for cardiovascular mortality by blood pressure and binge drinking habits using the Cox proportional hazard model. Binge drinkers and heavy binge drinkers were defined as having >/=6 drinks on 1 occasion and >/=12 drinks on 1 occasion.
RESULTS: After adjusting for total alcohol consumption, male heavy binge drinkers with Grade 3 hypertension had a 12-fold increased risk of cardiovascular mortality (HR, 12.7; 95% CI, 3.47 to 46.5), whereas male binge drinkers with Grade 3 hypertension had a 4-fold increased risk of cardiovascular mortality (HR, 4.41; 95% CI, 1.38 to 14.1) when compared with nondrinkers with normal blood pressure. However, in considering separate effects of heavy binge drinking and hypertension on the risk of cardiovascular mortality, HRs were rather low (HR of heavy binge drinkers, 1.88, 1.10 to 3.20; HR of hypertensives, 2.00, 1.70 to 2.35) compared with nondrinkers with normal blood pressure.
CONCLUSIONS: Binge drinkers and heavy binge drinkers with Grade 3 hypertension showed a marked increase in cardiovascular mortality risk. Even after adjusting for total alcohol consumption, the former revealed 4.41 and the latter indicated 12.7 of HR for the risk of cardiovascular mortality.
Additional Info
-
Authors
Sull J.W.; Yi S.W.; Nam C.M.; Choi K.; Ohrr H. -
Issue
Stroke / pages 2157-62 / 41(10) -
Published Date
19 august 2010
Related items
- A Mendelian randomization study of alcohol use and cardiometabolic disease risk in a multi-ancestry population from the Million Veteran Program
- Red Wine Consumption and the Impact on Cardiovascular Health: The Methodological Barriers of Observational Study Design
- Alcohol and Atrial Fibrillation: An Update and New Perspectives
- The role of social determinants in alcohol consumption and cardiovascular health: The pathways study
- Red Wine Consumption and the Impact on Cardiovascular Health: The Methodological Barriers of Observational Study Design