01 january 2023

Association between wine consumption and cancer: a systematic review and meta-analysis

BACKGROUND: Alcohol consumption is related to the risk of developing different types of cancer. However, unlike other alcoholic beverages, moderate wine drinking has demonstrated a protective effect on the risk of developing several types of cancer.

OBJECTIVE: To analyze the association between wine consumption and the risk of developing cancer.

METHODS: We searched the MEDLINE (through PubMed), Scopus, CochraneCochrane is a global independent network of health practitioners researchers patient advocates and o..., and Web of Science databases to conduct this systematic review and meta-analysis. Pooled relative risks (RRs) were calculated using the DerSimonian and Laird methods. I2 was used to evaluate inconsistency, the tau2 test was used to assess heterogeneity, and The Newcastle-Ottawa Quality Assessment Scale were applied to evaluate the risk of bias. This study was previously registered in PROSPERO, with the registration number CRD42022315864.

RESULTS: Seventy-three studies were included in the systematic review, and 26 were included in the meta-analysis. The pooled RR for the effect of wine consumption on the risk of gynecological cancers was 1.03 (95% CI: 0.99, 1.08), that for colorectal cancer was 0.92 (95% CI: 0.82, 1.03), and that for renal cancer was 0.92 (95% CI: 0.81, 1.04). In general, the heterogeneity was substantial.

CONCLUSION: The study findings reveal no association between wine consumption and the risk of developing any type of cancer. Moreover, wine drinking demonstrated a protective trend regarding the risk of developing pancreatic, skin, lung, and brain cancer as well as cancer in general.

SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022315864, identifier CRD42022315864 (PROSPERO).

Additional Info

  • Authors

    Luceron-Lucas-Torres M.; Cavero-Redondo I.; Martinez-Vizcaino V.; Bizzozero-Peroni B.; Pascual-Morena C.; Alvarez-Bueno C.
  • Issue

    Periodical: Front Nutr - Volume: 10 - Edition: 20230904
  • Published Date

    01 january 2023