Association between alcohol consumption and the risk of ovarian cancer: a meta-analysis of prospective observational studies
Background: Alcohol consumption has been inconsistently associated with the risk of ovarian cancer. The purpose of this study was to summarize the data from prospective cohort studies on the relationship between alcohol consumption and ovarian cancer using a meta-analytic approach.
Methods We performed electronic searches of PubMed, Embase, and the CochraneCochrane is a global independent network of health practitioners researchers patient advocates and o... Library in May 2014 to identify studies that examined the effects of alcohol consumption on the incidence of ovarian cancer. Only prospective cohort studies that reported effect estimates about the incidence of ovarian cancer with 95% confidence intervals (CIs) of alcohol intake were included.
Results Collectively, we included 13 prospective studies that reported on data from 1,996,841 individuals and included 5,857 cases of ovarian cancer. Alcohol consumption had little to no effect on ovarian cancer incidence when compared to non-drinkers (risk ratio [RR], 1.03; 95% CI, 0.96-1.10; P?=?0.473). Similarly, low (RR, 0.96; 95% CI, 0.93-1.00; P?=?0.059), moderate (RR, 1.08; 95% CI, 0.92-1.27; P?=?0.333), and heavy (RR, 0.99; 95% CI, 0.88-1.12; P?=?0.904) alcohol consumption was not associated with the risk of ovarian cancer. Furthermore, subgroup analyses suggested that low alcohol intake was associated with a reduced risk of ovarian cancer whereas heavy alcohol intake was associated with an increased risk of ovarian cancer in multiple subpopulations.
Conclusions: Our study suggests that alcohol intake is not associated with an increased risk of ovarian cancer. Subgroup analyses indicated that alcohol consumption might be associated with the risk of ovarian cancer in specific population or in studies with specific characteristics.
Additional Info
-
Authors
Huang Yan-Hong Li Jing Luan Hong Huang Shan-Shan Li Yan and Li Ju -
Issue
BMC Public Health 2015, 15:223 -
Published Date
2015
Related items
- Increasing rates of early-onset Luminal A breast cancers correlate with binge drinking patterns
- To Drink or Not to Drink? Investigating Alcohol’s Impact on Prostate Cancer Risk
- Alcohol Consumption and Cancer Risk: Two Sample Mendelian Randomization
- Joint association of drinking alcohol and obesity in relation to cancer risk: A systematic review and data synthesis
- Alcohol and colorectal cancer risk, subclassified by mutational signatures of DNA mismatch repair deficiency