Wine Information Council
29 june 2010
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Alcohol intake and endometrial cancer risk: a meta-analysis of prospective studies

BACKGROUND: Studies on alcohol intake in relation to endometrial cancer risk have produced inconsistent results.

METHODS: For a meta-analysis, we identified cohort studies of alcohol and endometrial cancer by a literature search of Pub-Med and Embase up to 1 March 2010 and by searching the reference lists of relevant articles.

RESULTS: Seven cohort studies, including 1,511,661 participants and 6086 endometrial cancer cases, were included in the dose-response random-effect meta-regression model. Compared with non-drinkers, women drinking less than 1 drink of alcohol (13 g of ethanol) per day had a lower risk for endometrial cancer; this risk was lower by 4% (95% confidence interval (95% CI): 0.93-1.00) for consumption up to 0.5 drink per day and by 7% (95% CI: 0.85-1.02) for consumption up to 1 drink. However, we found evidence of an increased risk for endometrial cancer for intakes higher than two alcoholic drinks per day: compared with non-drinkers, the risk was higher by 14% (95% CI: 0.95-1.36) for 2-2.5 drinks per day and by 25% (95% CI: 0.98-1.58) for >2.5 drinks per day.

CONCLUSION: Our meta-analysis indicates a possible J-shaped relationship between alcohol intake and endometrial cancer risk.

Additional Info

  • Authors

    Friberg E.; Orsini N.; Mantzoros C.S.; Wolk A.

  • Issue

    Br.J.Cancer / pages 127-131 / volume 103

  • Published Date

    29 june 2010

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