Wine Information Council
9 february 2015
Print

Alcohol intake and breast cancer in the European Prospective investigation into Cancer and Nutrition: Short title: Alcohol intake and breast cancer: Alcohol intake and breast cancer

Alcohol intake has been associated to breast cancer in pre and postmenopausal women; however results are inconclusive regarding tumor hormonal receptor status, and potential modifying factors like age at start drinking. Therefore, we investigated the relation between alcohol intake and the risk of breast cancer using prospective observational data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Up to 334,850 women, aged 35-70 years at baseline, were recruited in ten European countries and followed up an average of 11 years. Alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. The study outcomes were the Hazard ratios (HR) of developing breast cancer according to hormonal receptor status. During 3,670,439 person-years, 11,576 incident breast cancer cases were diagnosed. Alcohol intake was significantly related to breast cancer risk, for each 10g/day increase in alcohol intake the HR increased by 4.2% (95% CI: 2.7%-5.8%). Taking 0 to 5g/day as reference, alcohol intake of >5 to 15g/day was related to a 5.9% increase in breast cancer risk (95% CI: 1%-11%). Significant increasing trends were observed between alcohol intake and ER+/PR+, ER-/PR-,

Additional Info

  • Authors

    Romieu I.; Scoccianti C.; Chajes V.; de Batlle J.; Biessy C.; Dossus L.; Baglietto L.; Clavel-Chapelon F.; Overvad K.; Olsen A.; Tjonneland A.; Kaaks R.; Lukanova A.; Boeing H.; Trichopoulou A.; Lagiou P.; Trichopoulos D.; Palli D.; Sieri S.; Tumino R.; Vineis P.; Panico S.; Bueno-De-Mesquita H.B.; Gils C.H.; Peeters P.; Lund E.; Skeie G.; Weiderpass E.; Quiros J.R.; Chirlaque M.D.; Ardanaz E.; Sanchez M.J.; Duell E.J.; Amiano P.; Borgquist S.; Wirfalt E.; Hallmans G.; Johansson I.; Nilsson L.M.; Khaw K.T.; Wareham N.; Key T.J.; Travis R.C.; Murphy N.; Wark P.A.; Ferrari P.; Riboli E.

  • Issue

    Int.J Cancer 2015 Feb 9. doi: 10.1002/ijc.29469. [Epub ahead of print]

  • Published Date

    9 february 2015

Related items