Wine Information Council
january 2015
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Alcohol Consumption and the Risk for Developing Pancreatitis: A Case-Control Study in Japan

OBJECTIVE: This study aimed to estimate the association of alcohol consumption and pancreatitis in Japan.

METHODS: We performed a nationwide case-control study, which included 982 patients (574 patients with acute pancreatitis and 408 patients with chronic pancreatitis) and 1015 controls who were individually matched for sex, age, hospital, and time of their first hospital visit. Conditional logistic regression was used to assess the association of alcohol consumption and smoking with pancreatitis.

RESULTS: The patients had a mean (SD) age of 57.6 (17.0) years; 71.8% were male. Compared with nondrinkers, alcohol consumption of less than 20 g/d was not associated with the risk for total pancreatitis (odds ratio [OR], 1.0; 95% confidence interval [CI], 0.7-1.4). In patients with acute pancreatitis, the ORs (95% CI) for alcohol consumption of 20 </= approximately < 40 g/d, 40 </= approximately < 60 g/d, 60 </= approximately < 80 g/d, 80 </= approximately < 100 g/d, and 100 g/d or greater were 1.7 (0.9-3.0), 3.1 (1.6-5.9), 4.2 (2.1-8.2), 5.3 (2.4-12.0), and 6.4 (3.4-12.4), respectively. In patients with chronic pancreatitis, the ORs (95% CI) for alcohol consumption of 20 </= approximately < 40 g/d, 40 </= approximately < 60 g/d, 60 </= approximately < 80 g/d, 80 </= approximately < 100 g/d, and 100 g/d or greater were 2.6 (1.2-5.5), 3.2 (1.5-7.1), 9.2 (4.1-20.3), 13.0 (5.3-31.6), and 19.6 (8.2-46.8), respectively.

CONCLUSIONS: Our study precisely measured the quantitative effect of alcohol on the risk for developing pancreatitis.

Additional Info

  • Authors

    Kume K.; Masamune A.; Ariga H.; Shimosegawa T.

  • Issue

    Pancreas / pages 53-58 / volume 44

  • Published Date

    january 2015

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