Alcohol consumption, alcohol dehydrogenase and risk of coronary heart disease in the MONICA/KORA-Augsburg cohort 1994/1995-2002
BACKGROUND: Ample evidence exists for a protective effect of moderate alcohol consumption on cardiovascular risk. Recently, genotype of alcohol dehydrogenase 1C (ADH1C) has been reported to modify the impact of alcohol consumption on the risk of coronary heart disease (CHD). This study investigates whether ADH1C genotype modifies the effect of alcohol consumption on CHD risk and high-density lipoprotein (HDL) cholesterol level.
DESIGN: Prospective cohort study.
METHODS: Analyses of the joint effects of alcohol consumption and ADH1C genotype on CHD risk and HDL cholesterol level using Cox proportional hazards models and linear models.
RESULTS: Participants who were homozygous or heterozygous for the slow metabolizing gamma2-allele and reported alcohol intake of more than 14 g/day showed a 64% [hazard rate ratio (HRR), 0.36; 95% confidence interval (CI), 0.16-0.80] reduction in CHD risk. This effect was particularly pronounced in men (HRR, 0.27; 95% CI, 0.11-0.67). Women who reported alcohol intake > or =2 g/day showed a nonsignificant risk reduction (HRR, 0.39; 95% CI, 0.07-2.17). No significant interactions were found among alcohol consumption, ADH1C genotype, and HDL cholesterol levels.
CONCLUSIONS: In this study, alcohol dehydrogenase modifies the effect of alcohol consumption on coronary risk. The results support the protective effect of alcohol consumption on CHD risk and suggest a causal association of alcohol intake and lower CHD risk. The impact of ADH1C on the relationship between alcohol and HDL cholesterol is less clear.
Additional Info
-
Authors
Heidrich J.; Wellmann J.; Doring A.; Illig T.; Keil U. -
Issue
Eur.J.Cardiovasc.Prev.Rehabil. / pages 769-774 / volume 14 -
Published Date
december 2007
Related items
- Cardiovascular disease risk under low-fat, Mediterranean, and American Heart Association diets: a target trial emulation in United States adults
- Link between alcohol consumption and myocardial infarction, stroke, and all-cause mortality among Swedish male automotive workers over 30 years
- Global Geospatial Trends in Breast Cancer and Atrial Fibrillation/Flutter Among Older Women: Uncovering Shared Epidemiological Patterns and Etiological Links
- The interaction of age and total lifetime drinks is associated with regional cortical perfusion and thickness in healthy adults with low-level alcohol consumption
- Target Trial Emulation of Alcohol Intake Interventions in Young Adults and Risk of CVD over 30 years: Data from the CARDIA study