25 september 2021

A limitation of genetic epidemiological analysis when associations are genuinely J-shaped illustrated using a prospective study of alcohol consumption and vascular disease

Mendelian randomization, a commonly adopted approach in genetic epidemiology, is of value in distinguishing causal from non-causal associations. There are, however, limitations to the conclusions that can be drawn from this approach when the underlying relationship between an outcome and an exposure is non-linear. In this paper we explore a consequence of these limitations, illustrating these using a prospective epidemiological study of vascular disease in 500 000 Chinese people (the Kadoorie cohort).

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Authors

Frost C.; Wald N.
Issue

Int J Epidemiol . 2021 Sep 25;dyab162.
Published Date

25 september 2021

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