Adherence to the Mediterranean Diet and frailty criteria in an old population with metabolic syndrome: A cross-sectional analysis
OBJECTIVES: FrailtyFrailty is a clinical syndrome characterized by an age-related decline of multiple physiological fun... has emerged as a key indicator of biological aging. This study aimed to assess the relationship between MedDiet adherence and frailty prevalence in the context of metabolic syndrome (MetS).
DESIGN: Cross-sectional studyThe defining feature of a cross-sectional study is that it can compare different population groups a.... Baseline data from PREDIMEDThe PREDIMED study is one of the few randomized controlled trials about the Mediterranean Diet. More...-Plus trial SETTING: Primary care health, 23 recruitment sites (2013-2016).
PARTICIPANTS: A total of 6874 participants with overweight/obesity and >/=3 MetS components.
MEASUREMENTS: Adherence to the MedDiet: 17-item MedDiet score. FrailtyFrailty is a clinical syndrome characterized by an age-related decline of multiple physiological fun... and prefrailty (3 or 1-2 criteria): modified Fried FrailtyFrailty is a clinical syndrome characterized by an age-related decline of multiple physiological fun... Index (FFI), considering exhaustion, physical activity and functional capacity. Main independent variable was analysed: as a continuous variable (range: 0-17); in quartiles of adherence using univariate and multivariate logistic regression models adjusted for potential confounders.
RESULTS: Prefrailty and frailty prevalence were 49.7% and 2.9%, respectively. Compared to those with the lowest MedDiet adherence (0-6), participants with the highest adherence (11-17) had significantly lower odds of meeting frailty criteria. Fully adjusted models showed ORs of 0.479 (p = 0.097) for frailty, 0.705 (p = 0.001) for prefrailty, and 0.694 (p = 0.001) for frailty or prefrailty in participants with higher/greater MedDiet adherence. Each 1-point increase in the 17-item score was associated with an OR ranging from 0.878 to 0.977 (p < 0.05 for all comparisons, except functional capacity: p = 0.100). When adherence was dichotomized, the adjusted ORs ranged from 0.406 to 0.834 (p < 0.05 for all comparisons).
CONCLUSIONS: Higher adherence to MedDiet was associated with a lower prevalence of frailty and prefrailty in older adults with overweight/obesity and MetS, reinforcing its potential role in promoting healthy aging despite cardiometabolic comorbidities.
Additional Info
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Authors
Torrego-Ellacuria M.; Cuesta-Triana F.; Ortiz-Ramos M.; Martinez-Gonzalez M. A.; Corella D.; Vazquez-Lorente H.; Fito M.; Martinez J. A.; Tojal-Sierra L.; Warnberg J.; Vioque J.; Romaguera D.; Lopez-Miranda J.; Estruch R.; Tinahones F. J.; Santos-Lozano J. M.; Serra-Majem J. L.; Bueno-Cavanillas A.; Tur J. A.; Romero Vigara J. C.; Pinto X.; Gaforio J. J.; Vidal J.; Mas-Fontao S.; Daimiel L.; Chiva-Blanch G.; Basterra-Gortari J.; Gutierrez L.; Sorli J. V.; Minguella Munoz E.; Garcia-Rios A.; Bernabe Casanova A.; Gomez-Gracia E.; Zulet M. A.; Nafria M.; Casas R.; Garrido-Garrido E. M.; Goicolea-Guemez L.; Gomez-Perez A. M.; Ruiz-Canela M.; Megias I.; Valero-Barcelo C.; Montenegro Calvo M.; Pena-Orihuela P. J.; Tercero Macia C.; Razquin C.; Babio N.; Sala de Vedruna A.; Barabash A.; Matia-Martin P. -
Issue
Periodical: J Nutr Health Aging - Volume: 30 - Number: 2 - Edition: 20251217 -
Published Date
17 december 2025
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