Wine Information Council
june 2019
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The functional ALDH2 polymorphism is associated with breast cancer risk: A pooled analysis from the Breast Cancer Association Consortium

BACKGROUND: Epidemiological studies consistently indicate that alcohol consumption is an independent risk factor for female breast cancer (BC). Although the aldehyde dehydrogenase 2 (ALDH2) polymorphism (rs671: Glu>Lys) has a strong effect on acetaldehyde metabolism, the association of rs671 with BC risk and its interaction with alcohol intake have not been fully elucidated. We conducted a pooled analysis of 14 case-control studies, with individual data on Asian ancestry women participating in the Breast Cancer Association Consortium.

METHODS: We included 12,595 invasive BC cases and 12,884 controls for the analysis of rs671 and BC risk, and 2,849 invasive BC cases and 3,680 controls for the analysis of the gene-environment interaction between rs671 and alcohol intake for BC risk. The pooled odds ratios (OR) with 95% confidence intervals (CI) associated with rs671 and its interaction with alcohol intake for BC risk were estimated using logistic regression models.

RESULTS: The Lys/Lys genotype of rs671 was associated with increased BC risk (OR = 1.16, 95% CI 1.03-1.30, p = 0.014). According to tumor characteristics, the Lys/Lys genotype was associated with estrogen receptor (ER)-positive BC (OR = 1.19, 95% CI 1.05-1.36, p = 0.008), progesterone receptor (PR)-positive BC (OR = 1.19, 95% CI 1.03-1.36, p = 0.015), and human epidermal growth factor receptor 2 (HER2)-negative BC (OR = 1.25, 95% CI 1.05-1.48, p = 0.012). No evidence of a gene-environment interaction was observed between rs671 and alcohol intake (p = 0.537).

CONCLUSION: This study suggests that the Lys/Lys genotype confers susceptibility to BC risk among women of Asian ancestry, particularly for ER-positive, PR-positive, and HER2-negative tumor types.

Additional Info

  • Authors

    Ugai T.; Milne R. L.; Ito H.; Aronson K. J.; Bolla M. K.; Chan T.; Chan C. W.; Choi J. Y.; Conroy D. M.; Dennis J.; Dunning A. M.; Easton D. F.; Gaborieau V.; Gonzalez-Neira A.; Hartman M.; Healey C. S.; Iwasaki M.; John E. M.; Kang D.; Kim S. W.; Kwong A.; Lophatananon A.; Michailidou K.; Taib N. A. M.; Muir K.; Park S. K.; Pharoah P. D. P.; Sangrajrang S.; Shen C. Y.; Shu X. O.; Spinelli J. J.; Teo S. H.; Tessier D. C.; Tseng C. C.; Tsugane S.; Vincent D.; Wang Q.; Wu A. H.; Wu P. E.; Zheng W.; Matsuo K.

  • Issue

    Mol Genet Genomic Med. ;7(6):e707

  • Published Date

    june 2019

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