27 november 2014

Roles of alcohol consumption in fatty liver: A longitudinal study

BACKGROUND & AIMS: Roles of alcohol consumption in non-alcoholic fatty liver disease are still controversial, although several cross-sectional studies have suggested the beneficial effect of light to moderate drinking on fatty liver. We analyzed the longitudinal relationship between drinking pattern and fatty liver.

METHODS: We included 5297 Japanese individuals (3773 men and 1524 women) who underwent a baseline study in 2003 and follow-up at least once from 2004 to 2006. Generalized estimating equation was used to estimate any association between drinking pattern and fatty liver assessed by ultrasonography.

RESULTS: At baseline, 1179 men (31.2%) and 235 women (15.4%) had fatty liver; 2802 men (74.2%) and 436 women (28.6%) reported alcohol consumption. At the latest follow-up, 348 of 2594 men (13.4%) and 101 of 1289 women (7.8%) had newly developed fatty liver; 285 of 1179 men (24.2%) and 70 of 235 women (29.8%) demonstrated a remission of fatty liver. In men, drinking 0.1-69.9g/week (odds ratio, 0.79 [95% confidence interval, 0.68-0.90]), drinking 70.0-139.9g/week (0.73 [0.63-0.84]), drinking 140.0-279.9g/week (0.69 [0.60-0.79]), and drinking 280.0g/week (0.68 [0.58-0.79]) were inversely associated with fatty liver after adjusting for obesity, exercise, and smoking. In women, drinking 0.1-69.9g/week (0.71 [0.52-0.96]) and drinking 70.0-139.9g/week (0.67 [0.45-0.98]) were inversely associated with fatty liver after the adjustment.

CONCLUSIONS: Light to moderate alcohol consumption, or even somewhat excessive amounts especially in men, was likely to protect most individuals against fatty liver over time.

Additional Info

  • Authors

    Moriya A.; Iwasaki Y.; Ohguchi S.; Kayashima E.; Mitsumune T.; Taniguchi H.; Ando M.; Yamamoto K.
  • Issue

    J Hepatol. 2014 Nov 27. pii: S0168-8278(14)00874-5. doi: 10.1016/j.jhep.2014.11.025. [Epub ahead of print]
  • Published Date

    27 november 2014