Association between alcohol intake and risk for gastric cancer with regard to ALDH2 genotype in the Korean population
BACKGROUND: The relationship between alcohol intake and the risk for gastric cancer is not fully understood. The association between alcohol consumption and the risk for gastric cancer was investigated in the Korean population with the ALDH2 genotype.
METHODS: From 2003 to 2008, 445 patients with gastric cancer and 370 control subjects >/=50 years of age were included in the analysis. Logistic regression models including age, gender, education, smoking and drinking status, Helicobacter pylori infection and ALDH2 genotype were evaluated to estimate the adjusted odds ratios (ORs) for the development of gastric cancer.
RESULTS: For all subjects, the risk for gastric cancer was increased in ex-drinkers [OR 1.68, 95% confidence interval (CI) 1.07-2.64], but not in current drinkers. Subjects with inactive ALDH2 *2 allele(s) showed a lower level of alcohol consumption than ALDH2 *1/*1 homozygotes (P < 0.001). Among the ALDH2 *1/*2 carriers (n = 243), current/ex-drinkers had a significantly increased risk for gastric cancer compared with never/rare drinkers (OR 2.80, 95% CI 1.51-5.19). Among heavy drinkers (n = 115), ALDH2 *1/*2 heterozygotes had a 4-fold increased risk for gastric cancer compared with *1/*1 homozygotes (OR 4.26, 95% CI 1.10-16.47); however, no risk increase was seen among never/rare drinkers.
CONCLUSIONS: A dose-response association between alcohol intake and the risk for gastric cancer was not observed. However, ALDH2 polymorphisms were found to modify the susceptibility to the development of gastric cancer associated with alcohol intake, especially in case of ALDH2 *1/*2 genotype. The findings suggest an alcohol-ALDH2 genotype interaction in gastric carcinogenesis.
Additional Info
-
Authors
Shin C.M.; Kim N.; Cho S.I.; Kim J.S.; Jung H.C.; Song I.S. -
Issue
Int.J.Epidemiol. / pages 1047-1055 / volume 40 -
Published Date
august 2011
Related items
- Diet-wide analyses for risk of colorectal cancer: prospective study of 12,251 incident cases among 542,778 women in the UK
- Alcohol consumption trajectories and risk of breast cancer among postmenopausal women: a Danish cohort study
- Alcoholic beverage consumption and female breast cancer risk: A systematic review and meta-analysis of prospective cohort studies
- Is there a link between per capita alcohol consumption and cancer mortality?
- Increasing rates of early-onset Luminal A breast cancers correlate with binge drinking patterns