24 august 2010

Alcohol intake and risk of colorectal cancer: Results from the UK Dietary Cohort Consortium

BACKGROUND: Epidemiological studies have suggested that excessive alcohol intake increases colorectal cancer (CRC) risk. However, findings regarding tumour subsites and sex differences have been inconsistent.

METHODS: We investigated the prospective associations between alcohol intake on overall and site- and sex-specific CRC risk. Analyses were conducted on 579 CRC cases and 1996 matched controls nested within the UK Dietary Cohort Consortium using standardised data obtained from food diaries as a main nutritional method and repeated using data from food frequency questionnaire (FFQ).

RESULTS: Compared with individuals in the lightest category of drinkers (>0-/=45 g per day. No clear associations were observed between site-specific CRC risk and alcohol intake in either sex. Analyses using FFQ showed similar results.

CONCLUSION: We found no significantly increased risk of CRC up to 30 g per day of alcohol intake within the UK Dietary Cohort Consortium.

Additional Info

  • Authors

    Park J.Y.; Dahm C.C.; Keogh R.H.; Mitrou P.N.; Cairns B.J.; Greenwood D.C.; Spencer E.A.; Fentiman I.S.; Shipley M.J.; Brunner E.J.; Cade J.E.; Burley V.J.; Mishra G.D.; Kuh D.; Stephen A.M.; White I.R.; Luben R.N.; Mulligan A.A.; Khaw K.T.; Rodwell S.A.
  • Issue

    Br.J.Cancer / pages 747-756 / volume 103
  • Published Date

    24 august 2010