21 february 2012

Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body sizeThe EPIC-InterAct study

Objective: To investigate the association between alcohol consumption and type 2 diabetes, and determine whether this is modified by sex, body mass index (BMI) and beverage type. Design: Multicentre prospective case-cohort study.

Setting: Eight countries from the European Prospective Investigation into Cancer and Nutrition cohort. Subjects: A representative baseline sample of 16 154 participants and 12 403 incident cases of type 2 diabetes.

Interventions: Alcohol consumption assessed using validated dietary questionnaires. Main outcome measures: Occurrence of type 2 diabetes based on multiple sources (mainly self-reports), verified against medical information.

Results: Amongst men, moderate alcohol consumption was nonsignificantly associated with a lower incidence of diabetes with a hazard ratio (HR) of 0.90 (95% CI: 0.78-1.05) for 6.1-12.0 versus 0.1-6.0 g day(-1) , adjusted for dietary and diabetes risk factors. However, the lowest risk was observed at higher intakes of 24.1-96.0 g day(-1) with an HR of 0.86 (95% CI: 0.75-0.98). Amongst women, moderate alcohol consumption was associated with a lower incidence of diabetes with a hazard ratio of 0.82 (95% CI: 0.72-0.92) for 6.1-12.0 g day(-1) (P interaction gender <0.01). The inverse association between alcohol consumption and diabetes was more pronounced amongst overweight (BMI >/= 25 kg m(-2) ) than normal-weight men and women (P interaction < 0.05). Adjusting for waist and hip circumference did not alter the results for men, but attenuated the association for women (HR=0.90, 95% CI: 0.79-1.03 for 6.1-12.0 g day(-1) ). Wine consumption for men and fortified wine consumption for women were most strongly associated with a reduced risk of diabetes.

Conclusions: The results of this study show that moderate alcohol consumption is associated with a lower risk of type 2 diabetes amongst women only. However, this risk reduction is in part explained by fat distribution. The relation between alcohol consumption and type 2 diabetes was stronger for overweight than normal-weight women and men.

Additional Info

  • Authors

    Beulens J.W.; van der Schouw Y.T.; Bergmann M.M.; Rohrmann S.; Schulze M.B.; Buijsse B.; Grobbee D.E.; Arriola L.; Cauchi S.; Tormo M.J.; Allen N.E.; van der A.DL; Balkau B.; Boeing H.; Clavel-Chapelon F.; de Lauzon-Guillan B.; Franks P.; Froguel P.; Gonzales C.; Halkjaer J.; Huerta J.M.; Kaaks R.; Key T.J.; Khaw K.T.; Krogh V.; Molina-Montes E.; Nilsson P.; Overvad K.; Palli D.; Panico S.; Ramon Quiros J.; Ronaldsson O.; Romieu I.; Romaguera D.; Sacerdote C.; Sanchez M.J.; Spijkerman A.M.; Teucher B.; Tjonneland A.; Tumino R.; Sharp S.; Forouhi N.G.; Langenberg C.; Feskens E.J.; Riboli E.; Wareham N.J.
  • Issue

    J Intern Med. /page 422
  • Published Date

    21 february 2012