In this clinical study, twelve healthy volunteers were supplemented with non-alcoholic red wine extract, including resveratrol and polyphenols for eight weeks. Blood samples were taken at the start and 4 and 8 weeks after the supplementation.
The beneficial effects of red wine are thought to be exerted through polyphenols. Among the polyphenols, resveratrol has been one of the most extensively studied and is regarded as one that contributes to the health benefits of red wine. Thus, polyphenols including resveratrol from red wine may improve changes associated with aging such as parameters related to inflammation and cardiovascular health.
The results demonstrated that such a supplementation could improve the blood parameters involved in glucose and lipid metabolism, increase insulin sensitivity and reduce inflammation parameters. The authors caution, however, that these observed results need to be confirmed in a larger clinical study.
Kitada, M. et al, 2020, Supplementation with red wine extract increases insulin sensitivity and peripheral blood mononuclear Sirt1 Expression in nondiabetic humans, Nutrients, 12, 3108; https://doi.org/10.3390/nu12103108